Cannabidiol and Fibromyalgia

More than 100 cannabinoids have been identified in the cannabis plant, i.e. chemical compounds that are found in natural form in the aforementioned plant. One of the most noteworthy is cannabidiol (CBD), which can represent up to 45% of the plant extract. Many of the cannabis sativa strains have CBD or cannabidiol, but they do so in small quantities. In fact, only some branches of the plant contain a sufficient concentration of CBD, so that it can be extracted in a useful form.


The first time that CBD was isolated from the cannabis plant was between 1930 and 1940, by researchers from the University of Illinois (USA). However, its structure and chemical composition was not known until the 1960s, when they were identified by Professor Rafael Mechoulam. Since 2013, PubMed, a U.S. medical research database, has cataloged more than 1,500 cannabidiol studies. In this sense, many scientists claim that CBD is one of the most important cannabinoids discovered today.

THERAPEUTIC EFFECTS OF CANNABIDIOL

In comparison with other cannabinoids, cannabidiol has acquired a lot of importance in the therapeutic field, as it lacks the psychoactive properties typical of THC (since it does not act through the brain's CB1 receptors, responsible for psychoactivity), which can be reduced when used together CBD and THC.

In this way, similar quantities of CBD and THC (ratio of 1: 1 or even higher than THC) can be administered, without strong negative effects due to high amounts of THC appearing (such as the psychoactive effect, tachycardia, attacks of anxiety and others).

Although much remains to be investigated on the properties of cannabidiol, there are several studies that have proven its benefits from a clinical point of view.

Its most important therapeutic effects derive from its properties:


Fibromyalgia
anxiolytic
analgesic
antiemetic
antiepileptic
antitumor
antioxidant
inflammatory
antipsychotic
immunomodulator
antibacterial and antifungal
neuroprotective
antirheumatic
sleep inducer


Although not all the benefits of cannabidiol are fully known, investigations have existed that have demonstrated its clinical benefits. For example, experts have revealed its relationship with the immune system. Thus it has been proven that, in some cell lines of the immune system, CBD has the ability to inhibit the production of certain cytokines (IL-8, IL-10, TNF-D, IFNJ). These tests directly link that CBD has beneficial effects on inflammatory / autoimmune diseases. Therefore, CBD has anti-inflammatory, analgesic, anxiolytic and antipsychotic properties. There are also studies that have linked cannabidiol to the relief of chronic pain or for the treatment of epilepsy, among other diseases.

Other research has focused on the effects of cannabidiol on arthritis. Thus, a study in rats showed that a treatment with CBD (both orally and intraperitoneally) had blocked the disease, paralyzing its growth. These effects are linked to the immunosuppressive activity and the anti-inflammatory property of this cannabinoid.

In a disease like cancer, CBD produces a sedative effect in most cases and inhibits the transmission of nerve signals associated with pain. CBD has been noted to reduce the growth of human breast cancer cells in vitro and in vivo in rats, and reduce its invasiveness.

HOW TO USE CANNABIDIOL

There are different products in the market that contain CBD derived from certified hemp. CBD oil is one of the best known products. To use it, you can ingest or use as a compound in cream and ointment, spray, tea or hemp infusions. The effect of cannabidiol occurs within 15 to 30 minutes of intake.

In the case of the spray, its operation is very simple. It is a matter of applying under the tongue (sublingual) the dose prescribed by the specialist doctor. In the case of infusions, it is a question of preparing a conventional infusion, adding some kind of milk or fat, such as butter, to make this cannabinoid dissolve properly.

Although CBD is still studied in countries around the world, in Spain products composed with CBD and THC (the latter with less than 0.2%) can be consumed legally and do not require a prescription to be purchased. It is a pharmacological solution developed by GW Pharma and composed of CBD and THC (1:1 ratio), recommended in the treatment of pain and spasticity in people with multiple sclerosis

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